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| Contact info |
Address: Strengthens the Effective Road Guzhen County, Bengbu, Anhui, China
Contact: Mr Guo
Tel: +86-552-6023123
Mobile: +86-18655256462
Code: 233700 |
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| Macropore adsorptive resin technology used in extracting traditional Chinese medicine |
1, The theory of Macropore adsorptive resin:Macropore adsorptive resin is a kind of new technique developed in the 1970s. Simply speaking, it is a kind of purifying and refining method: make the boiled Chinese traditional medicine liquid pass macropore resin and absorb its valid ingredients. According to the different compositions of the drug liquid, different materials extracted, different kinds of resin is chosen. Absorptive resin, especially the ingredients of non-polar adsorptive resin in absorptive liquor, which is decided by physical structure(surface, pore diameter) etc.. AB-8 is usually used in extracting stevia sugar, while X-5 is often used in extracting antibiotics. Its basic operating procedures are: extracting solution of Chinese traditional medicine——through macropore resin——absorb the effective composition of resin——eluting——eluting liquor——Retrieve the solution ——medicine liquor——drying——semi products. At present this technology is widely used in developing new drugs and Chinese patent medicine and mainly used in separation and extract.
2, The advantages of macropore absorptive resin in Chinese traditional medicine: The extract and separation is the most important step in the production of Chinese patent medicine. It is also the crucial problem in improving quality of Chinese traditional medicine because it can directly affect the products’ quality and clinical effect. In past 30 years, old technique for extracting Chinese traditional medicine is still used today. The main factors that prevent Chinese traditional medicine being exported are that Chinese traditional medicine has many impurities, large amount of use level and black in color. Compared with traditional impurity-removing method, macropore resin absorptive technologies have the following strong points:
Firstly, it can reduce dosage and improve the quality and preparing level of Chinese traditional medicine. The substance refined by macropore resin absorptive technology can increase the density of drug effect and reduce impurities.
Secondly, reduce products’ absorption of moisture. Chinese patent medicine prepared by traditional technique has strong absorption of moisture, which is a problem always existing in the storage of Chinese patent medicine. Macropore resin absorptive technology can effective remove moisture-absorbing ingredients such as sugar, inorganic salts and lymphatic temperament. This can enhance the products’ stability.
Thirdly, Macropore resin absorptive technology can shorten production cycle. And what it needs is simple equipment. It can save costs of packaging and a lot of work, which established conditions to enter international market.
3, The application of macropore resin absorptive resin and the drug effect and the precautions in application: It is proved in clinical observation that a set of mature technique procedures can not only guarantee the drug effect, but also improve the drug effect. But, there are a lot of problems we should pay attention to, such as what kind of resin we should choose. The specification and quality of resin play a crucial role in the purifying effect and safety of extract liquor of Chinese traditional medicine. Different kind of resins have different performances. Extract liquor of Chinese traditional medicine is very complicated, so one kind of resin is not necessary for refining and purifying. During the process of purifying and refining, related pharmacodynamics test methods should be chosen in accordance with the kind of disease. Meanwhile, valid chemical ingredients of drugs should be chased. The valid ingredients can be ensured not to lose in the purifying and refining process. In order to guarantee drug quality, we should choose best conditions for use level, maximum absorptive amount, absorbing and eluting speed, height and diameter of resin columnar, type of eluting liquor. Only the correct technique conditions can guarantee the good drug effect.
4, Problems existing in the application of macropore resin absorptive resin: The technological dispute of macropore resin absorptive focuses on the toxicity of hole-making agent and degrading agent. The resin is the net-structured, the hole is relatively big. Some organic solvent should be added in preparation. Most of these organic solvents are the poisonous liquid. They stay in the space of the resin. Usually we call them hole-making agent, which a lot of people worry about. If we can not remove the hole-making agents completely before we use it, the pollution problems will appear. We have got some treating methods for hole-making agents and degrading substance after many times test. We have made a whole set of testing method and the quality control standard for benzene and toluene etc.. In most production, a kind of resin is only used in extracting and refining one kind of drugs. The absorptive amount has drawn great attention. But the problems can be solved if the resin is treated and changed in time.
5,The prospect of macropore absorptive resin technology:
The substance got from the separation technique of macropore resin is small in volume easy to be made into various kinds of beautiful form of drug in appearance, especially suitable to granule and tablet. For macropore resin itself, its craft is easy and simple to handle. And the resin can be used many times. The cost is not very high, the equipment is relatively easy and convenient and this kind of technique can save lots of expenses of energy consumption, auxiliary materials, wrappings, preserving and transportation etc.. At present, macropore adsorptive technology is widely used in the production of western medicine. In China, more and more enterprises started to macropore resin technology in researching and producing Chinese traditional medicine. So, the application of macropore adsorptive resin technology has a bright future.
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